Small extracellular vesicles (sEVs), operationally referred to as exosomes, where strict biogenesis-based classification cannot be confirmed from the primary literature, are pivotal mediators of intercellular communication in cancer, transferring a diverse epigenetic payload that encompasses noncoding RNAs (ncRNAs), DNA fragments, chromatin-modifying enzymes, and metabolic effectors, which reprogram the recipient cell's chromatin architecture without altering the underlying DNA sequence. sEVs or