Growth arrest specific 6 ameliorated inflammation and portal pressure through activating efferocytosis in cholestasis and portal hypertension
Gu-Qing Luo·Lei Zheng·Zheng-Hao Wu·Jia-Yun Lin·Chi-Hao Zhang·Guang-Bo Wu·Qiang Fan·Xiao‐Liang Qi·Hong-Jie Li·Meng Luo·Jin-Bo Zhao
BACKGROUND Portal hypertension (PHT) is a complication of chronic liver disease. PHT was observed from the early stage of cholestatic liver disease (CLD). Growth arrest specific 6 (Gas6)-mediated macrophage efferocytosis was an essential process clearing apoptotic cells and facilitating liver injury repair. AIM To investigate the effects of recombinant Gas6 (rGas6) on efferocytosis in PHT based on mice models of cholestasis. METHODS The cholestasis models were established by bile duct ligation (