Introduction: Liver cirrhosis is a chronic, progressive disorder marked by extensive hepatic fibrosis and profound metabolic disturbances. Among these alterations, Branched-chain Amino Acids (BCAAs)—leucine, isoleucine and valine—undergo significant dysregulation, reflecting compromised hepatic function, altered nitrogen metabolism and muscle catabolism. Advances in metabolomic technologies have facilitated the accurate quantification of BCAA levels, highlighting their potential as sensitive bio