Association of NLRP3 rs10754558 polymorphism with inflammasome-related cytokine responses in chronic spontaneous urticaria

Background Chronic spontaneous urticaria (CSU) is a clinically heterogeneous inflammatory condition affecting the skin, in which mechanisms beyond histamine-mediated mast cell activation are increasingly recognized. Dysregulation of innate immune pathways, including inflammasome signaling, may contribute to disease pathogenesis. Within the inflammasome family, NOD-like receptor pyrin domain–containing protein 3 (NLRP3) rs10754558 polymorphism has been implicated in altered cytokine responses in