From mechanisms to therapies: exploiting epigenetic and post-translational modifications of mitochondrial quality control in diabetic kidney disease

Diabetic kidney disease (DKD) is a major and severe microvascular complication of diabetes and one of the primary causes of end-stage renal failure. As the body’s largest metabolic organ, the kidneys require a continuous supply of energy to maintain systemic homeostasis and normal metabolic functions. The mitochondrial quality control (MQC) system plays a central role in preserving cellular energy homeostasis by regulating key processes such as mitochondrial biogenesis, dynamics, and mitophagy,