LMS-based continuous reference values for the myokine musclin in serum in children and adults
Anne Schön·Maren Leifheit-Nestler·Katharina Schermuly·Anna Tschirner·Malgorzata Szaroszyk·Thomas Rebe·Jens Drube·N K Kanzelmeyer·Ulrich Baumann·Anibh M. Das·Dieter Haffner·Hannah Weber
Background Musclin is a myokine which is linked to muscle activity and systemic metabolic regulation. Age-specific reference values for serum musclin are lacking in both the pediatric and adult population, limiting the interpretation of circulating musclin concentrations in clinical practice and studies. Objectives To establish Lambda–Mu–Sigma (LMS)-based continuous age-specific reference values for serum musclin in children and adults. Methods Musclin concentrations were measured in serum by en