Paeoniflorin Ameliorates Cecal Ligation and Puncture-Induced Acute Lung Injury in Mice by Modulating Oxidative Stress, Apoptosis, and Inflammation: Shedding Light on the Role of the JAK2/STAT3 Pathway
Nourhan Hisham Shady·Dalia H. Abu‐Baih·Nehad M. Reda Abdel Reda Abdel Maqsoud·Peter A. Sidhom·Mahmoud A. A. Ibrahim·Ahmed M. Shawky·Mohamed Hisham·Gerhard Bringmann·Usama Ramadan Abdelmohsen·Reham H. Mohyeldin
Background: Acute lung injury (ALI) is a major complication of sepsis, driven by oxidative stress, inflammation, and apoptosis. Paeoniflorin, a monoterpenoid glycoside, has demonstrated notable antioxidant and anti-inflammatory properties, suggesting potential therapeutic value in ALI. Methods: Sepsis-induced ALI was established in mice using the cecal ligation and puncture (CLP) model. The protective effects of paeoniflorin were evaluated by measuring oxidative stress markers (SOD, GSH, and MDA