Background: Acute lung injury (ALI) is a major complication of sepsis, driven by oxidative stress, inflammation, and apoptosis. Paeoniflorin, a monoterpenoid glycoside, has demonstrated notable antioxidant and anti-inflammatory properties, suggesting potential therapeutic value in ALI. Methods: Sepsis-induced ALI was established in mice using the cecal ligation and puncture (CLP) model. The protective effects of paeoniflorin were evaluated by measuring oxidative stress markers (SOD, GSH, and MDA
Paeoniflorin Ameliorates Cecal Ligation and Puncture-Induced Acute Lung Injury in Mice by Modulating Oxidative Stress, Apoptosis, and Inflammation: Shedding Light on the Role of the JAK2/STAT3 Pathway
Nourhan Hisham Shady·Dalia H. Abu‐Baih·Nehad M. Reda Abdel Reda Abdel Maqsoud·Peter A. Sidhom·Mahmoud A. A. Ibrahim·Ahmed M. Shawky·Mohamed Hisham·Gerhard Bringmann·Usama Ramadan Abdelmohsen·Reham H. Mohyeldin