Benefits of Regular Intake of Glucolacto-Oligosaccharides on Gut Health in Adults with Low Defecation Frequency: A Randomized, Double-Blind, Placebo-Controlled Study
Yuichi Yoshizawa·Kenichi Hojo·Atsushi Shimonaka·Satoshi Hanamura·Akika Nagira·Mami Minakata·Akiko Koizumi·Aoi Fujieda·Hiroki Negishi·Shigenori Kanemura·Seiya Makino·Junya Ishida
The significance of less abundant genera within the gut microbiota, such as Parabacteroides, remains largely unexplored. Despite its low levels, Parabacteroides is highly conserved and potentially beneficial across populations. This trial aimed to evaluate whether a four-week intake of glucolacto-oligosaccharides (GLO), previously reported as an enhancer of Parabacteroides, improves defecation frequency as the primary outcome. It also assessed holistic gut health and underlying microbiota-based