Bifidobacterium breve MN15965 Improved Bacterial Diversity, Short-Chain Fatty Acid Production, and Immune Activation in a Cyclophosphamide-Induced Immunosuppression Mouse Model
Tinghao Liu·Li X·Yan Hui·Jing Yang·Jianqiang Li·Haisang Qin·Ke Zhao·Jinjun Li·Xiangyu Bian·Xin Wang·Yuling Li·Fangshu Shi·Yuejian Mao·Xinyi Zhao
The gut microbiota serves as a critical interface for host immunity, making it a promising target for probiotic intervention. In this study, we investigated the immunomodulatory potential of the strain Bifidobacterium breve (B. breve) MN15965 and the underlying role of gut bacterial communities in this process. We first assessed its in vitro immunomodulatory activity by measuring nitric oxide and cytokine secretion in THP-1 macrophages. Subsequently, an immunosuppressed mouse model was establish