Anthocyanins are plant polyphenols widely regarded as antioxidants, yet they can exert concentration-dependent effects and act as pro-oxidants in specific contexts. Although their protective role in stressed testicular cells is established, their impact on Leydig cell steroidogenesis under non-pathological conditions remains poorly understood. Here, we investigated how an anthocyanin-enriched fraction from Callistemon citrinus (0–1.00 μg/mL) affects androgen synthesis in murine TM3 Leydig cells.
Pro-Oxidant Anthocyanins-Enriched Fraction Inhibits Androgen Synthesis by Transcriptional Repression of Cyp17a1 Through Nr0b2
Giuseppe T. Patanè·M Fátima Alves·Ana D. Martins·Stefano Putaggio·Davide Barreca·P Guedes de Oliveira·Ruben J. Moreira

