Engineered Nanomicelles Prevent Colorectal Liver Metastasis via Inhibiting the Premetastatic Niche and Regulating the Metabolic Homeostasis

Colorectal liver metastasis is one of the major causes of poor survival in colorectal cancer patients as it causes organ dysfunction and disrupts metabolic homeostasis. Apart from the primary tumor microenvironment (TME) challenges arising from cell proliferation, immunosuppression, and angiogenesis, premetastatic niches also represent an attractive therapeutic target for preventing liver metastasis. Here, we present the engineering of a unique, highly stable sub-100 nm three-drug-loaded nanomic