Human seasonal H3N2 influenza A viruses (IAV) are repeatedly transmitted to swine. Modern indoor swine production facilitates close contact between human employees and pigs in their care during certain husbandry events, like weaning, that may increase the chance of interspecies transmission of IAV. This study investigated the effect of matched and mismatched maternal-derived antibodies (MDA) acquired from homologous and heterologous vaccinated sows on piglet susceptibility to a human-like H3N2 v