Clinical connectomics: Mapping structural brain networks in disease

The human connectome holds considerable promise for advancing an integrated, systems-level understanding of brain disorders. Critical to this ambition is accurate, reliable, and biologically informative connectome mapping and analysis in the presence of diverse brain pathologies. However, many connectome-mapping methodologies have been established and validated using healthy, non-clinical participants. Here, we consider the challenges of structural connectome mapping in the presence of pathology