Cutaneous melanoma is a highly metastatic cancer which had limited treatment options until the advent of immune checkpoint inhibitors (ICI); however, only around 50% of patients respond. Natural killer (NK) cells are potent cytotoxic and cytokine producing lymphocytes which present a promising avenue for immunotherapy. However, the progressive dysfunction of NK cells during cancer development represents a major barrier to effective autologous therapies. This study investigated the metabolic and