Biological validity, test–retest reliability, and behavioral relevance of the single-subject brain volumetric similarity network

The T1-weighted brain magnetic resonance imaging (MRI)-based volumetric similarity network (VSN) offers an advantage in clinical settings due to its ease of acquisition and widespread availability. However, its validity, reliability, and behavioral relevance remain unclear. The present study aimed to assess the reproducibility and utility of the VSN as a foundation for future research and clinical applications. Here, we analyzed three datasets (total N = 354), with two datasets having repeated M