High ovarian cancer cell glucocorticoid receptor (GR) expression is associated with reduced progression-free survival (PFS) despite standard debulking surgery and adjuvant chemotherapy. Although not previously linked to tumor-cell GR expression, a "cold" (immune-suppressive) ovarian cancer tumor microenvironment (TME) is also associated with poor prognosis. In this study, analysis of The Cancer Genome Atlas (TCGA) ovarian cancer database revealed that NR3C1 (GR) mRNA was positively correlated wi
Ovarian cancer cell glucocorticoid receptor activation increases myeloid-derived suppressor cell tumor infiltration
Manisha Taya·Larissa Belova·Edward B. Gray·Lynda Bennett·Tryambak Srivastava·Andrew DeVilbiss·Gini F. Fleming·Woei-Yaw Chee
