Neutrophil–Pancreatic Cancer Interplay Defines a Microenvironmental Axis that Sustains Neutrophil Survival and Pro-tumorigenic Reprogramming

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of only 13%. Tumor-promoting inflammation and immune evasion are hallmarks that contribute to tumor survival, proliferation, and metastasis and are driven by infiltrating leukocytes and the release of pro-inflammatory cytokines into the tumor microenvironment. Among the infiltrating leukocytes, neutrophils play a critical role in inflammation and immunoregulation, exhibiting both p