Objectives Osteoarthritis (OA) is a common degenerative joint disorder characterized by the breakdown of articular cartilage and bone hypertrophy. Matrix metalloproteinase-13 (MMP-13) and interleukin-6 (IL-6) are two biomolecules that have been linked to the pathogenesis of OA. The early diagnosis and management of OA are critical to prevent disease progression and maintain quality of life. MMP-13 is a key enzyme that contributes to the degradation of cartilage extracellular matrix components, w