Cardiac Wire

Hypertension has long been tied to cognitive decline, but new research in JAHA suggests it’s actually hypotension that carries the strongest association with Alzheimer’s disease. To map the relationship between CVD subtypes and Alzheimer’s risk, researchers analyzed EHR data across a UK Biobank and All of Us cohort to examine a wide range of cardiovascular […] The post Low Blood Pressure’s Alzhei…

Pay-for-performance programs (a form of value-based care) are supposed to improve patient care, but a new JAMA study suggests that one hypertension control incentive might be making the numbers look better while actually increasing hospitalizations. In an effort to evaluate pay-for-performance, researchers compared outcomes across 334k patients at 103 primary care practices before and after […] T…

America’s cardiovascular burden from rising temperatures is set to nearly triple by 2050, with a new JAMA Cardiology study predicting thousands more CV deaths per year due to high-emissions and climate change. To model the scale of the problem, researchers analyzed heat-related CVD across 3.1k U.S. counties using Global Burden of Disease data from 2010–2016 […] The post It’s Getting Hot in Here, …

Most microplastic research usually focuses on tissue build-up, but a new Circulation study suggests Bisphenol F (BPF) damages our heart muscle through an unexpected pathway in the gut. To determine if BPF causes harm, researchers first examined its prevalence in humans and then used germ-free mouse models and single-cell sequencing to map BPF’s path from […] The post One Microplastic’s Way to You…

Much like a beating heart, cardiology never stops. Whether it’s debate about technology, therapy, or ethics, cardiologists are some of the most vocal and passionate members of the medical community, and their opinions can be found across X, LinkedIn, and beyond. Regardless of platform, this list of top cardiology resources should keep you well-informed about […] The post The 40 Best Cardiology Re…

Heart failure inflammation might actually be an underrecognized therapeutic target, after analysis of the POSEIDON registry found that systemic inflammation is present in nearly half of heart failure patients, regardless of ejection fraction. To explore inflammation prevalence, the POSEIDON registry analyzed 11.8k heart failure patients with available hsCRP readings and found that their inflammat…

It might feel like a transcatheter alphabet soup out there with all of the valve interventions that have come out in the last few years, but Cardiac Wire is here to help make sense of it all. Currently, all four heart valves have options for transcatheter replacement, though the availability and prevalence of these procedures […] The post Cardiac Wire’s State of The Transcatheter Valve appeared f…

Despite a TAVR popularity surge in recent years, a Vizient registry analysis suggests the procedure’s prevalence has stabilized in patients under 65, but there’s still significant debate on whether the young patient TAVR rate is appropriate. Getting to the bottom of the TAVR question, researchers examined aortic valve replacement procedures in under-65 patients from 2016-2024 […] The post The You…

Data from a new Lancet study suggests that patients with chronic kidney disease (CKD) might get similar cardiovascular protection from blood pressure drugs as the general population, giving physicians some certainty about how to approach BP in these patients. Constructing a massive meta-analysis, researchers examined 285k patients to see how BP lowering (using five antihypertensive […] The post B…

The question of how to treat non-obstructive hypertrophic cardiomyopathy has long perplexed researchers and pharmaceutical developers alike, but topline results from Cytokinetics’ Phase 3 ACACIA-HCM trial suggest MYQORZO (aficamten) could be the answer. For Cytokinetics, aficamten already saw success in obstructive HCM, so the hypothesis of ACACIA-HCM was simple – can the drug help patients […] T…

It’s not often that a pair of studies completely challenges our assumptions in cardiology, but new data presented at HRS 2026 suggests myocardial infarction might not be the main cause of sudden cardiac death (SCD). Despite how far cardiology has come in treating the heart, annual SCD incidence remains high. This prompted researchers to continuously […] The post The True Cause of Sudden Cardiac D…

The Heart Rhythm Society’s Annual Meeting for 2026 electrified Chicago with talks of the latest EP tech, rhythm management debates, and insights into where remote patient monitoring is headed. Here are Cardiac Wire’s top-six takeaways from electrophysiology’s biggest weekend of the year. HRS Grows Steadily – This year’s HRS attendance numbers hit just over 10k, […] The post Cardiac Wire’s Top Six…

Cardiac troponin assays might be the gold standard for diagnosing a heart attack in the ER, but a new JAMA study suggests the latest generation of tests could significantly reduce false positives and ultimately, health system burden. To address this, researchers compared how the newest sixth generation hs-cTnT assay (which used a 13-ng/L cut off […] The post Better hs-cTnT Assays, Lower Healthcar…

While the verdict is still out on whether or not calcium supplements support bone health, new research in JAHA suggests they’re not good for your heart. Since there’s little known about the effects of calcium supplements on the heart, researchers performed an observational analysis of EHR data from 237k patients in Hong Kong, 16% of […] The post Calcium Supplements May Have CV Risks appeared firs…

We’re finally starting to get some real-world data on treating tricuspid regurgitation with transcatheter tricuspid valve replacement (TTVR) and a new TVT registry study suggests TTVR outcomes are even better than previously thought. The TVT Registry analysis followed the 30 day outcomes of 1,034 patients with symptomatic, severe TR who were treated with Edwards’ EVOQUE […] The post A Look Into R…

Intravascular lithotripsy is becoming a game of giants after Stryker’s announcement that it will acquire Amplitude Vascular Systems (AVS) for an undisclosed amount to add the company’s IVL system to its peripheral vascular portfolio. This acquisition may be unique in its PAD scope, since other IVL acquisitions tend to revolve around CAD or CAD+PAD, but […] The post Stryker Steps into IVL with AVS…

We all know there’s a growing cardiologist shortage, but American cardiovascular care might hit its breaking point, with a Medicus Healthcare Solutions analysis now projecting that the shortage will only get bigger, and will hit rural communities the hardest. To quantify the problem, Medicus examined over 34k U.S. cardiologists (24.9k general, 5.2k interventional, 2.9k electrophysiologists) […] T…

UPMC’s structural heart president, Hemal Gada, MD, might have been terminated for whistleblowing, according to a federal lawsuit that alleges retaliatory firing following his reports of conflicts of interest regarding Edwards Lifesciences and alleged racism within UPMC. The whistleblower retaliation suit details how Dr. Gada originally criticized Edwards’ SAPIEN 3 valve clinical trial data on […]…

ACC.26 saw an overall drop in research fervor, but one long-awaited study, CHAMPION-AF, spurred a new discussion around the field of left atrial appendage closure and the data we’ve used to justify the procedure. - Left atrial appendage closure (LAAC) uses an implantable device (like Boston Scientific’s Watchman) to close off a pocket of tissue on the left atrium of the heart. - This potentially …

Cardiology came back to New Orleans with ACC.26 and amid the magic of “The Big Easy” some more subtle trends emerged, reflecting a maturation of cardiac science and business. Here are Cardiac Wire’s top takeaways from the conference. - A Drop in Late-Breakers: This year only saw 27 late-breakers presented, down from ACC.25’s record-breaking 53, with an even split between procedures (13) and pharm…