Frontiers in Systems Neuroscience | New and Recent Articles

IntroductionUnilateral cerebral palsy (UCP) results from early brain injury, leading to motor impairments primarily affecting one upper limb. Action Observation Therapy (AOT), which engages the mirror neuron system to enhance motor function, represents a promising rehabilitative approach. However, its efficacy in UCP has been inconsistent across studies, possibly due to methodological differences…

BackgroundUnconscious/implicit processes are increasingly conceptualized as biologically instantiated, multisystem regulatory functions rather than purely psychological constructs. This review examines whether an integrative framework linking psychoneuroimmuneendocrine (PINE) regulation, epigenetic mechanisms, and principles of morphogenetic organization can help organize evidence relevant to “un…

Valence detection in complex environment is critical for natural behaviors like foraging. Previous studies have explored valence processing in brain regions like lateral horn (LH) and mushroom body (MB) using simple synthetic stimuli in Drosophila. However, the neural basis for valence detection of natural objects in complex contexts remains unclear. Here, by brain-wide connectome analysis, we id…

Learning disabilities in children are exhibited through difficulties in reading and writing due to lack of cognitive skills. It is generally diagnosed by analyzing the behavior and processing capacity of children by understanding their academic candidature. This can also be evidenced by capturing and analyzing their working memory patterns in the brain that show the effectiveness of therapeutic i…

Recent interdisciplinary research has raised interest in whether non-classical physical principles may impose fundamental constraints on how neural information can be observed, extracted, or decoded. While conventional neuroscience models neural signaling primarily through classical electrochemical processes, a growing body of theoretical literature has speculated that quantum-mechanical concepts…

Brain function is not simply the sum of individual neuronal activities, but rather emerges from functional neural circuits comprising thousands to millions of neurons with specific topological structures and dynamic properties. Investigating the functions and information-processing architectures of these neural circuits is essential for understanding how the brain performs “computation” and “oper…

PurposeElectrooculography (EOG) provides a noninvasive measure of eye movements linked to affective processing, yet it is mainly used for artifact correction of electroencephalography (EEG) signals rather than analyzed as a physiological signal in its own right. EEG–EOG coupling has therefore not been well-established. This study aimed to determine whether emotion-specific changes in arousal and …

Pyramidal cells in the dorsal hippocampus (dCA1) are excitatory neurons modulated by environmental cues. While a population of dCA1 cells encodes spatial location, other groups are activated by reward probability and encounters. Since “rewards” are predicted at “locations,” we sought to determine how spatiotemporal coding patterns in the dCA1 resolve contextual preference and subsequent change in…