Nature Communications, Published online: 03 June 2026; doi:10.1038/s41467-026-73543-w Gouty arthritis faces multiple challenges such as recalcitrance to cure and recurrent flares, with studies often focusing on urate reduction, pain relief, or anti-inflammatory effects alone. Here, authors develop a manganese platinum microscale galvanic cell as a multifunctional therapeutic strategy for the treatment of gouty arthritis.