Enantioconvergent vinylcyclopropane–cyclopentene rearrangement with vessel-controlled chemodivergence
Ying Xia
Nature Chemistry, Published online: 17 April 2026; doi:10.1038/s41557-026-02132-7 The vinylcyclopropane–cyclopentene (VCP–CPent) rearrangement is a fundamental method for constructing five-membered carbocycles from vinylcyclopropanes. Now an enantioconvergent VCP–CPent rearrangement has been developed, enabling the conversion of racemic VCP into chiral cyclopentene products. Vessel-controlled chemodivergence selectively delivers either gem-difluorocyclopentenes or cyclopentenones from identical