Vessel material determines product of enantioselective vinylcyclopropane rearrangement
Michael Martin Nielsen
Nature Chemistry, Published online: 17 April 2026; doi:10.1038/s41557-026-02134-5 Vinylcyclopropane-cyclopentene rearrangements provide access to five-membered carbocycles, yet enantioselective variants have largely been confined to electronically activated substrates. Now, a rhodium-catalysed enantioselective rearrangement of gem-difluorocyclopropanes proceeds with a striking chemodivergence, depending on whether the reaction is performed in glass or plastic.