Differences among canine serum, plasma and urine metabolite profiles from samples that were collected at the same time
Anna Hielm-Björkman
BackgroundBiospecimen choice can substantially influence metabolite measurements, yet matched comparisons of serum, EDTA plasma, lithium-heparin plasma, and urine remain limited in canine targeted metabolomics.ObjectivesTo evaluate cross-matrix comparability of targeted small polar metabolite profiles in dogs and to assess how different biospecimens capture diet- and health-associated variation.AnimalsClient-owned dogs from a previously reported feeding trial.MethodsTargeted ultra-performance li