The OPERA project: a harmonized multinational real-world ART database across Italy and Germany (2016–2020) and a descriptive snapshot of contemporary clinical practice
OPERA Working Group
IntroductionAssisted reproductive technology (ART) practice varies widely across centers and evolves rapidly, often outpacing the generation of randomized evidence. OPERA (Observational ProjEct for a Research database for ART procedures) was developed to create a harmonized, multinational real-world database derived from routine clinical ART documentation and to provide a structured overview of contemporary clinical practice.Materials and methodsOPERA is a retrospective, multicenter database inc