Abstract: Metabolic syndrome and excessive alcohol consumption lead to liver injury and fibrosis, characterized by increased collagen deposition from hepatic stellate cells
Shubham Ghosh Roy
https://doi.org/10.1172/JCI197923 Here, David A. Brenner & team discover the RNA-binding protein LARP6 as a master coordinator of hepatic stellate cell activation and fibrosis, using human tissue and liver spheroid models of MASH and MetALD. The image shows collagen labeling (red) in human liver spheroids MASH model with LARP6-targeting ASO (DAPI, blue). Collagen labeling is decreased […]