Single-gene systems-level effects, and more
Jill Adams
Opposite day: Neurodevelopmental conditions may arise from disruptions in the systems-level maturation of neuronal circuits, according to a new preprint. The investigators compared the effects of SYNGAP1 haploinsufficiency in mice with the effects of SYNGAP1 disruption in cortical excitatory neurons. The former induced two altered and opposing patterns of neuronal activity in the cortex, whereas the latter induced only one change. Altered SYNGAP1 functioning during this developmental window of..