An AI framework for multi-disease detection via retinal imaging

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04424-4 Using large-scale retinal images from community and tertiary hospitals, we developed Reti-Pioneer, a quality-aware, multi-task framework for multi-disease detection. Diverse external validation confirmed its generalizability. Furthermore, a prospective silent trial and clinical pilot study demonstrated its time efficiency, real-world feasibility, and potential for integration into clinical workflows.