Diffusion MRI sampling schemes bias diffusion metrics and tractography
Fernanda Tovar-Moll
IntroductionDiffusion MRI is increasingly used to study white-matter architecture, but tractography and diffusion metrics can be biased by different sampling schemes. We assessed systematic differences across four common protocols—single-shell high-angular resolution diffusion imaging (HARDI), Siemens clinical multi-shell (Sms), diffusion spectrum imaging (DSI), and Human Connectome Project multi-shell (HCPms)—in healthy adults and individuals with corpus callosum dysgenesis (CCD).MethodsAll dat