UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity
Noam Shemesh
Nature Communications, Published online: 04 May 2026; doi:10.1038/s41467-026-71506-9 UFLARE is a fMRI method that dissociates bottom-up from top-down signals by tracking ultrafast information flow across cortical layers. Validated across brain systems and injury models, it enables studying brain communication, learning, and disease.