Synthese 207 (6):240. 2026No-lose arguments state that—no matter what the result of an experiment will be—there will be a relevant epistemic gain if the experiment is performed. Here I provide an analysis of such arguments, looking at examples from particle physics. I argue that no-lose arguments indicate the pursuitworthiness of experiments by partially decoupling the expected epistemic gain of an experiment from the ex-ante probability that the primarily intended outcome is achieved. While a
