Nuclease–NTPase antiphage defence systems use conserved molecular features to control bacterial immunity

Philip J. Kranzusch
Nature Microbiology, Published online: 27 April 2026; doi:10.1038/s41564-026-02312-8 A large-scale, comparative cell biology and biochemical screen defines the molecular features controlling antiphage defence systems that encode nuclease effectors and accessory NTPase proteins.