Focal white matter lesions drive grey matter inflammation and synapse loss
Ragnhildur Thóra Káradóttir
Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10414-w A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.