Deep learning guided propofol ketamine dosing and inflammation trajectories in elderly burns
Wenjing Miao
Background and objectivesElderly patients (≥65 years) who sustain burn injuries encounter a clinically significant perioperative challenge: a dysregulated hyperinflammatory response, characterized by elevated levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), compounded by a markedly reduced hemodynamic reserve. Both propofol and low-dose ketamine exhibit distinct anti-inflammatory mechanisms; however, the optimization of their combined dosing with