Ecotoxicology and Environmental Safety

Arsenic (As) is carcinogenic toxicity and widespread in soils due to intensive arsenical pesticide application and industrial activities. Pteris vittata ( P. vittata ) is the first reported As hyperaccumulator. Phytoremediation efficiency of As-contaminated soils using P. vittata depends on rhizosphere As mobilization, root-to-shoot translocation (uptake and redox), and detoxification (methylatio…

Mycotoxin and pesticide co-contamination represents a critical threat to aquatic ecosystem integrity, yet the toxicological effects and underlying mechanisms of T-2 toxin (T-2) and diniconazole (DIN), two widely coexisting agricultural contaminants, remain elusive. Here, adult male and female zebrafish were exposed to T-2 (4.25 μg L⁻¹), DIN (32.79 μg L⁻¹), or their combination for 60 days to inve…

Following global and domestic regulations on legacy plasticizers (LPs), such as di(2-ethylhexyl) phthalate (DEHP), the environmental emergence of alternative plasticizers (APs) has become a critical concern. This study investigated the spatial distribution, source, long-term trends (2008–2024), and ecological risks of 15 LPs and 20 APs in sediments from a highly industrialized artificial lake in …

Background Environmental and dietary exposure to sulfamethoxazole (SMX) has been detected in pregnant populations, but its impact on preeclampsia (PE)-related placental pathology—particularly through non-therapeutic chronic exposure—remains poorly understood. Methods We assessed the effects of maternal SMX exposure on placental structure in pregnant mice. Placental transcriptomic data and Mendeli…

Contamination of freshwater ecosystems by microplastics has become a significant global issue. This study investigates the abundance, distribution, and characteristics of microplastics in the surface water and sediments of the Densu River during both wet and dry seasons. Surface water and sediment samples were collected from ten (10) sites in the Densu River and processed using density separation…

Apolygus lucorum has become an economically damaging pest due to the lack of efficacy in currently used Bacillus thuringiensis (Bt) cotton varieties and the reduced application of broad-spectrum insecticides. Mpp51Aa (Cry51Aa) proteins are promising insecticidal candidates with specific activity against hemipteran pests, including A. lucorum. However, the molecular mechanisms of their toxicity an…

aphid life history traits. Adult longevity significantly decreased in all treated insects relative to the control. Mean fecundity declined from 42.39 nymphs/female in the control to 2.38 nymphs/female in the combined treatment. The intrinsic rate of increase (r) was markedly reduced, falling from 0.23 d⁻¹ in the control to -0.003 d⁻¹ in the combined treatment. Overall, the combined treatment outp…

BACKGROUND: Organophosphate esters (OPEs) are globally used flame retardants and plasticizers with widespread human exposure. Whether OPE exposure affects survival in advanced high-grade serous ovarian cancer (HGSOC) and the underlying mechanisms remains unclear. We aimed to identify prognosis-related OPEs and explore their biological actions. METHODS: We conducted a nested case-control study wit…

Short-chain chlorinated paraffins (SCCPs) have attracted extensive attention due to their wide distribution and associated human exposure risks. Although marine bivalves exhibit a high accumulation capacity for SCCPs, their toxicological effects and underlying mechanisms remain poorly understood. To address this, the accumulation, toxicity, and molecular mechanisms of SCCPs were evaluated by usin…

The role of reproductive hormones in the associations of air pollution with oocyte-related outcomes remains unclear. In 6376 women undergoing assisted reproductive technology, we investigated the mediating role of reproductive hormones in the association between air pollutants during the 90 days pre-retrieval to gonadotropin start and oocyte-related outcomes. Results showed that nitrogen dioxide …