Biochemical and Biophysical Research Communications

Statins are widely prescribed to those with atherosclerosis to lower cholesterol and reduce cardiovascular risk, but their influence on plaque calcification remains unclear. While clinical data associate statin use with increased calcium scores and reduced cardiovascular events, their effect on rupture-prone microcalcifications has not been clinically assessed due to imaging limitations. In vitro…

Recent studies have revealed important roles of promoter-associated long noncoding RNAs (lncRNAs) in the regulation of adjacent genes. One of the first such RNA identified is the metabolic stress-induced lncRNA (mlonRNA) in fission yeast, which is involved in the activation of the fbp1 gene under glucose starvation. Whether this promoter-associated lncRNAs function through the RNA molecule itself…

Epitranscriptomic RNA modifications form a dynamic regulatory layer that shapes gene expression and cellular function. While N6-methyladenosine (m⁶A) has been extensively studied, other modifications-including m⁵C, m¹A, m³C, m⁷G, and Ψ-play critical roles in RNA folding, stability, translation, and stress responses. Initially, studies focused…

Precise quantification of circulating peptide hormones is essential for understanding their physiological functions. Although the fruit fly Drosophila melanogaster is a powerful genetic model that has greatly contributed to animal physiology, measuring endogenous peptide hormone titers in the hemolymph has remained technically challenging because of its small body size. Neuropeptide F (NPF), a co…