Infectious Diseases and Therapy

Pertussis (whooping cough), a vaccine-preventable disease that affects people of any age, has resurged globally after the COVID-19 pandemic. Key reasons for recent pertussis outbreaks include suboptimal pertussis vaccination coverage (particularly for vaccination during pregnancy) and growing vaccination hesitancy. During the 2023–2024 pertussis outbreaks in Europe, adolescents aged 10–14 years a…

Integrating RSV vaccination into routine immunization schedules, alongside other key vaccines, is essential for achieving comprehensive and optimal protection for older adults in GCC countries.

International Standard Randomised Controlled Trial Number Registry: ISRCTN53375662.

Tetracyclines may provide therapeutic options for refractory or MDR-related BJIs, and for suppressive therapy when surgical or antibiotic alternatives are limited. However, available data are heterogeneous and largely observational. Robust prospective studies are needed to clarify their role, particularly for newer agents such as omadacycline and eravacycline.

Among hospitalized older adults, RSV infection carries considerable morbidity and mortality and may have a higher risk for poor clinical outcomes compared with influenza. These findings support the prioritization of RSV vaccination programs among older adults.

Modeling different testing strategies allows outbreak control programs to quantify the impact of trade-offs between accessibility, affordability, and speed of diagnosis in different outbreak settings.

These findings demonstrate the program's success in reducing disease burden and enhancing immunization rates, underscoring the superior protection of two-dose vaccination and providing strong evidence for policymakers to expand such initiatives.

In this large national cohort, severe COVID-19 risk increased with the number of risk factors present. Patients with multiple overlapping risk factors who were not vaccinated were at the highest risk for severe COVID-19. As recommendations have shifted toward risk-based clinical decision-making, identifying patients with particularly high-risk combinations of conditions is increasingly important …

High positivity rates for HIV, HBV and HCV were observed among migrants in France who underwent community-based testing. This suggests that such screening can effectively target this population and provide an opportunity to access appropriate support. Graphical abstract available for this article.

In this large, contemporary US cohort, ART regimen switching was somewhat common and most frequently occurred among virologically suppressed PWH. These real-world findings on the incidence and patterns of virologically suppressed switches provide insight into new trends in treatment optimization and the need for new therapeutic options.

Universal nirsevimab prophylaxis markedly reduced the burden of respiratory infections in eligible infants, leading to a significant reduction in the use of healthcare resources, including ED visits, hospitalization, and PICU admissions.

Switching to B/F/TAF from NNRTI-based regimens, particularly if RPV-based, showed high virological effectiveness and rare treatment discontinuations. No resistance mutations were detected at failure.

Based on data collected during this occupational testing protocol, our study provides strong evidence supporting real-world performance of this test in an asymptomatic population. These findings, complemented by data from an existing clinical study, provided the totality-of-evidence that supported the US Food and Drug Administration clearance for the expanded claim of the candidate test for the q…

Viral hepatitis remains a significant challenge for global public health and a leading cause of liver-related morbidity and mortality worldwide, with most cases caused by five hepatotropic viruses: hepatitis A, B, C, D, and E. The World Health Organization has established a goal to eliminate viral hepatitis as a public health threat by 2030. In recent years, advancements in our understanding of i…

HMPV poses a significant burden on vulnerable groups in Spain. Despite underdiagnosis, rising cases post-COVID highlight the need for targeted prevention. These findings offer a foundation for public health planning and vaccine prioritization.