Journal of Clinical Medicine

Background/Objectives: Textbook outcome (TO) is an all-or-none composite in which a common, practice-sensitive component may exert disproportionate influence on patient classification. We evaluated the classification impact of binary postoperative intensive care unit (ICU) admission and the additional information retained by actual ICU duration after colorectal cancer surgery. Methods: This retro…

Background/Objectives: Days alive and out of the hospital at 30 days (DAOH30) integrates survival, index hospitalization, and readmission. We characterized DAOH30 after gastrectomy, assessed its complication-severity gradient and readmission burden, and explored its association with an index-cancer-excluded Charlson Comorbidity Index (CCI). Methods: This single-center retrospective analysis inclu…

Background/Objectives: Noninvasive prenatal screening (NIPS) fails in approximately 0.2% of cases due to high maternal plasma total cell-free DNA (t-cfDNA) concentration (≥0.6 ng/µL) confirmed after two DNA extraction attempts. The clinical implications of this quality control metric for fetal growth restriction (FGR) remain unknown. Methods: This retrospective cohort study, conducted in a major …

Background/Objectives: There is limited understanding of how periodontitis progresses in individuals with diabetes who are undergoing antiresorptive drug therapy, particularly given that both are risk factors for medication-related osteonecrosis of the jaw (MRONJ). This study evaluated the effect of therapy with an oncological dose of zoledronate on the progression of experimental periodontitis (…

Purpose: The purpose of this study is to evaluate anatomical, visual, and safety outcomes after repeat pars plana vitrectomy combined with 360° encircling scleral buckling for first recurrent rhegmatogenous retinal detachment following primary vitrectomy. Methods: This retrospective single-centre cohort included 47 eyes of 47 patients treated between October 2016 and October 2023. The primary out…

Objectives: The present study investigated whether the pre-treatment Advanced Lung Cancer Inflammation Index (ALI) could serve as a prognostic indicator of disease-free survival (DFS) in patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy followed by curative D2 gastrectomy. Methods: We retrospectively analyzed 157 patients with gastric adenocarcinoma who received …

Background/Objectives: Hepatic steatosis and metabolic dysfunction-associated steatotic liver disease (MASLD) are cardiometabolic phenotypes relevant to atrial fibrillation (AF), but their prevalence and acute procedural relevance in pulsed field ablation (PFA) are poorly defined. We estimated the prevalence of hepato-renal index (HRI)-detected hepatic steatosis, assessed liver marker concordance…

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment patterns, survival outcomes, and prognostic factors of male breast cancer patients treated at a tertiary referral center.…

Background: Chronic spontaneous urticaria (CSU) is an immune-mediated disorder driven by mast cell activation, whereas abnormal uterine bleeding (AUB) is a heterogeneous condition with diverse etiologies. Although immune and inflammatory dysregulation has been independently implicated in CSU and certain forms of AUB, the association between CSU and AUB remains unclear. We therefore examined wheth…

Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB) present with similar clinical and radiological features, frequently leading to misdiagnosis. This study aimed to compare NTM-PD with extrapulmonary NTM disease (ENTM) and PTB and to develop a predictive model for early differentiation. Methods: We retrospectively analyzed 473 NTM patients (340 NTM…

Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review was conducted using the PubMed database, including studies published up to August 2026. The search used combinations of …

Background/Objectives: Despite the excellent long-term outcomes of total knee arthroplasty (TKA), up to 10% of patients remain dissatisfied. Robotic-assisted TKA enables individualized alignment strategies, such as functional alignment (FA). Proper alignment and soft tissue balance are considered key factors for positive clinical outcomes. This study compared medial and lateral ligament balance b…

Background/Objectives: Sodium–glucose cotransporter-2 (SGLT2) inhibitors improve cardiorenal outcomes in patients with diabetes, heart failure, and chronic kidney disease. Their association with perioperative outcomes after major cardiac procedures remains uncertain. Methods: In this retrospective cohort study using the TriNetX U.S. Collaborative Network, adults (≥18 years) undergoing cardiac pro…

Background/Objectives: Kidney transplantation is the gold standard treatment for end-stage renal failure. Numerous studies have sought to identify biomarkers that can predict early outcomes. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker that is hypothesised to be an important predictor of early surgical outcomes. Methods: A targeted narrative search was performed using prespeci…

Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that manifests differently across sexes, potentially impacting symptomatology, diagnosis, and treatment. Nevertheless, these legitimate sex differences in ADHD are further shaped by multiple sources of bias that distort prevalence estimates and clinical recognition. Methods: This critical review…

Group 3 pulmonary hypertension is a common and clinically significant complication of chronic lung disease and hypoxia that is associated with impaired functional capacity, right ventricular dysfunction, and increased mortality. Historically viewed as a consequence of underlying parenchymal lung disease, Group 3 pulmonary hypertension is now recognized as a complex disorder involving pulmonary va…

Background/Objectives: The optimal intracoronary drug delivery strategy for the management of the no-reflow phenomenon (NRP) during percutaneous coronary intervention (PCI) remains uncertain. We compared distal and proximal intracoronary drug administration for the treatment of NRP. Methods: This retrospective single-center study included 212 consecutive patients who developed NRP following drug-…

Objectives: This study evaluated the association between maintenance therapy and survival outcomes following first-line bevacizumab-based combination chemotherapy in metastatic colorectal cancer (mCRC) using real-world data. Methods: This retrospective study included 94 mCRC patients achieving disease control, defined as complete response (CR), partial response (PR), or stable disease (SD), after…

Background: Severe obesity is a chronic condition that adversely affects physical health and quality of life, including sexual function. However, its impact on multidimensional psychosexual outcomes remains unexplored. This study aimed to assess changes in erectile function, genital self-image, and psychological distress in men who underwent bariatric surgery. Methods: This prospective cohort stu…

Objectives: This systematic review synthesized the existing literature to evaluate the associations between maternal Selenium (Se) exposure during pregnancy and neonatal outcomes, specifically focusing on parameters of mortality, morbidity, and neurobehavioral development. Methods: PubMed, Embase, and the Cochrane Library were systematically searched from inception through December 2025. For qual…