Asian Spine Journal

PRAs were not associated with worse outcomes after LIF and were linked to greater improvement in PROMIS scores. Psychiatric history, but not allergy count, was a strong predictor of reduced MCID attainment.

A multimodal approach combining comprehensive bone quality assessment, systemic anabolic optimization (moderate certainty evidence), and targeted novel biologics delivered via advanced biomaterial scaffolds (very low certainty evidence) is proposed for optimized spinal arthrodesis outcomes. However, large-scale clinical trials are required to validate these emerging biologic enhancers.

We propose a functional hierarchy of spinopelvic parameters based on their observed heterogeneity-from stable "core" to variable "adaptive" components. Future research is warranted to validate the potential population-invariance of currently underreported bicoxofemoral axis-referenced parameters and to evaluate whether correction strategies focused on these stable elements improve surgical outcom…

PELD may provide sustained symptom relief and low rates of complication, recurrence, and reoperation in long-term follow-up. Late clinical and functional outcomes appear to be favorable. However, the predominance of retrospective data and selective loss to follow-up limits the strength of the conclusions.

UH allows high resection rates, neurological improvement, low morbidity, and durable mechanical stability in intradural tumors, supporting its use as a tissue-preserving alternative to wider posterior exposure.

cAAI poses additional challenges over other forms of AAI given its corresponding abnormal bony and vascular anatomy. Thorough planning and anatomical restoration are essential for satisfactory outcomes.

Minimally invasive spine surgery (MISS), supported by advancements in endoscopic systems, tubular retractors, lateral access corridors, image-guided navigation, and robotic assistance, has progressively expanded its role in the management of a broad spectrum of spinal disorders. These approaches were developed to limit muscular disruption and soft tissue damage while maintaining clinical and radi…

A posterior approach with our novel PASR fixation system is safe and effective for the treatment of AAD. Compared with a conventional PASR fixation system, our novel PASR fixation system can simplify the operation and provide a better reduction effect. This novel fixation system is expected to facilitate the procedure of atlantoaxial fixation and achieve reduction of irreducible AAD without relea…

Intradiscal MSC injection appears to be a safe and effective therapy, offering modest improvements in pain and function for patients with CLBP due to DDD who do not respond to conservative treatments.

This study experimentally validated the "safe zone" hypothesis, confirming its presence and effectiveness. In cases of screw breach, the decision for revision surgery should be based on the patient's clinical condition and breach status (vessel displaced or injured), rather than the screw position alone. However, if a vertebral artery injury is suspected, acute intervention should be initiated pr…

LF in HD patients exhibits B2M amyloid and AGE accumulation with upregulation of RAGE-related inflammatory genes and proteins, especially on the dorsal side. LF hypertrophy in dialysis-related LSCS appears to represent an inflammatory-amyloid phenotype, indicating the AGE-B2M-RAGE pathway as a potential therapeutic target.

Preoperative LF thickness at L2/3 and cranial adjacent facet degeneration predicted postoperative LF hypertrophy progression after PLIF. Both inherent predisposition and mechanical stress may contribute to adjacent-level LF thickening.