World Journal of Gastrointestinal Surgery

BACKGROUND Laparoscopic surgery is the standard therapy for gastrointestinal (GI) cancers; however, its application in gallbladder cancer (GBC) remains cautious, and its clinical advantages require further validation. AIM To compare surgical performance, postoperative recovery, and complication rates between patients with early GBC undergoing laparoscopic radical cholecystectomy (LRC) and those r…

BACKGROUND Visceral adiposity is implicated in colorectal cancer (CRC) progression and metabolic dysregulation. However, the dynamic interplay between visceral fat area (VFA), perioperative skeletal muscle loss (SML), and long-term survival remains poorly defined. This study aimed to elucidate the impact of VFA on SML and its prognostic value in CRC patients. AIM To investigate the impact of VFA …

BACKGROUND Intraductal papillary mucinous neoplasms (IPMNs) are precursors of pancreatic ductal adenocarcinoma and often harbor KRAS and GNAS mutations. Although disease progression may take a decade or longer, very late recurrence after curative resection is rare. The treatment options for older patients remain limited due to their poor tolerance to standard chemotherapy. CASE SUMMARY Herein, we…

BACKGROUND Robotic surgery has been widely used in pylorus-preserving gastrectomy (PPG). Segmental gastrectomy (SG) is a classic surgical method in PPG. Indocyanine green (ICG) can increase the number of lymph nodes dissected. CASE SUMMARY We report ICG tracer-guided SG using a robotic system in a 62-year-old female patient with early gastric cancer. It took 23 minutes for robotic setup, 130 minu…

The Frey procedure (pancreatic head coring with longitudinal duct drainage) provides sustained pain control for selected patients with chronic pancreatitis. The single-center cohort by Eppa et al. , published in the recent issue of the Euroasian J Hepatogastroenterol discussed in this letter, long-term follow up showed marked and durable reductions in validated pain scores and improvements in hea…

The rising incidence of gastric cancer in an aging population poses a significant surgical challenge, as elderly patients often present with greater comorbidities, leading to concerns about their ability to tolerate standardized enhanced recovery after surgery (ERAS) protocols. The groundbreaking retrospective study by Li et al , directly addresses this critical evidence gap. Their study demonstr…

Liver transplantation (LT) is a complex surgical procedure often accompanied by massive intraoperative blood loss, necessitating transfusion of blood and blood products. However, transfusion of allogeneic blood has been consistently associated with adverse outcomes, including increased post-transplant morbidity and mortality, higher rates of infection, acute kidney injury, and reduced graft survi…

BACKGROUND Total laparoscopic distal gastrectomy (TLDG) is increasingly used for advanced gastric cancer, but its comprehensive outcomes vs open distal gastrectomy (ODG) require further validation. AIM To investigate the perioperative safety, postoperative recovery, and mid-term survival between TLDG and ODG for locally advanced gastric cancer. METHODS This retrospective study analyzed patients a…

BACKGROUND The effective treatment of perianal fistulas while ensuring sphincter preservation remains challenging. Radiofrequency ablation (RFA) is a promising approach; however, its clinical translation is limited because energy settings have been extrapolated from non-fistulous tissues, and most probes deliver only focal heating. We designed a 50-mm segmental RFA catheter to achieve maximal gra…

BACKGROUND Pancreatic cancer is one of the most aggressive malignancies, and surgery remains the only potentially curative treatment. However, postoperative complications, psychological distress, and treatment-related symptoms can severely impair quality of life (QoL) of patients. Although psychological interventions and health education have shown beneficial effects in other cancer populations, …

BACKGROUND Aggressive recurrence after liver resection (LRE) in hepatocellular carcinoma (HCC) is associated with unfavorable clinical outcomes. Intratumoral fibrosis (ITF) is mechanistically associated with aggressive recurrence, promoting immunosuppression, angiogenesis, and matrix stiffening, thereby supporting its potential as a predictive biomarker. AIM To develop and validate a competing ri…

BACKGROUND Obturator hernia is an abdominal wall hernia in which intra-abdominal contents protrude through the obturator foramen of the pelvis into the femoral triangle region, which is bounded by the inguinal ligament, medial border of the adductor longus muscle, and medial border of the sartorius muscle. Femoral hernia occurs when a hernia sac passes through the femoral ring and descends along …

Endoscopic submucosal dissection is a key technique for the minimally invasive treatment of early-stage gastric cancer. Offering the advantages of minimal trauma, high safety and the ability to resect tumours intact, it has been incorporated into standard treatment protocols in many countries. This article systematically reviews the clinical value, recent developments and controversies surroundin…

BACKGROUND Hepatocellular carcinoma (HCC) incidence continues to rise, yet treatment options remain limited. Despite recent advances in early screening methods, most patients are still diagnosed at an advanced stage with poor prognosis. Therefore, accurate assessment of prognostic risk using molecular biomarkers is essential for the development of personalized treatment strategies. AIM To investi…

BACKGROUND Postoperative gastrointestinal dysfunction is common in patients with colorectal cancer (CRC). Transcutaneous electrical acupoint stimulation (TEAS) is a noninvasive therapy derived from acupuncture. AIM To evaluate the effects of TEAS applied at Zusanli and Neiguan as an adjunct to anesthesia on postoperative qi-blood harmonization and spleen–stomach function recovery in patients with…

BACKGROUND Traumatic subserosa hematoma of the proximal jejunum with delayed rupture and hemorrhage is exceedingly rare, especially without anticoagulation. No prior reports document spontaneous rupture precisely on day 5 post-blunt trauma. This case uniquely demonstrates this delayed pattern, initial computed tomography (CT) misdiagnosis as a retroperitoneal neoplasm due to Treitz ligament proxi…

Bariatric surgery is recognized as the most effective surgical strategy for achieving sustained weight loss and improving metabolic disorders in patients with severe obesity. Beyond anatomical restriction and caloric malabsorption, increasing evidence suggests that surgery-induced remodeling of the gut microbiota plays a critical role in mediating postoperative metabolic benefits. Initial studies…

BACKGROUND Agitated behaviour is a common and challenging complication in elderly patients with liver cirrhosis who present with acute haemorrhage in an emergency setting. It not only hinders medical care but also increases the risk of adverse clinical outcomes. Nursing interventions may play a role in managing this agitation and improving clinical outcomes. We hypothesized that a comprehensive n…

BACKGROUND Acute necrotizing pancreatitis (ANP), a more severe form of acute pancreatitis, requires early diagnosis and accurate severity stratification for optimal patient prognosis and treatment. Currently, most scholars do not clearly differentiate between ANP and severe acute pancreatitis, although they are distinct clinical entities. AIM To investigate the value of radiomics derived from con…

BACKGROUND Clinically significant portal hypertension (CSPH) drives major complications in cirrhosis. While hepatic venous pressure gradient is the gold standard for CSPH diagnosis, its invasiveness limits routine use. Liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) offer non-invasive alternatives, but their utility in tracking transjugular intrahepatic portosystemic shun…