European Journal of Clinical Pharmacology

Abstract Purpose High-dose methotrexate is an effective treatment for adult and pediatric patients with acute lymphoblastic leukemia, osteosarcoma, and lymphoma. However, its clearance is highly variable, and delayed clearance can lead to significant toxicity. This study aimed to identify a population pharmacokinetic model that accurately characterizes high-dose methotrexate clearance in an adult…

Abstract Purpose An increasing number of anecdotal reports on social media platforms and medical blogs describe dysesthesia, particularly burning skin sensations, in association with glucagon-like peptide-1 receptor (GLP-1R) agonists. We performed a pharmacovigilance data-mining analysis to characterise cases of dysesthesia related to GLP-1R. Methods We conducted a disproportionality analysis usi…

Abstract Purpose Medication adherence is essential for treatment effectiveness, yet the uptake of adherence-supporting tools in routine care remains suboptimal. This study assessed Italian healthcare professionals’ knowledge, perceived utility, and willingness to recommend medication adherence tools, and explored perceived barriers to their adoption. Methods A questionnaire targeting healthcare p…

Abstract Objective To estimate the short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval (QTc) by emulating a published randomized controlled trial (RCT) using electronic health record (EHR) data, and to assess whether target trial emulation (TTE) can replicate RCT findings for a pharmacological safety outcome at substantially greater scale. Design Retrospective cohor…

Abstract Purpose To evaluate the possible influence of gender and specialty on adverse drug reaction (ADR) reporting among physicians before and after the COVID-19 pandemic. Methods This retrospective nationwide register study analysed all ADR reports submitted by physicians to the Swedish Medical Products Agency during 2017 and 2023 ( n = 4079 and 3740, respectively). The reporting rates were ca…

Abstract Purpose This study aimed to describe the role and perceptions of clinical pharmacologists (CPs) in conducting economic evaluations of health technologies within the Spanish National Health System from a healthcare provider perspective. Methods We conducted a cross-sectional descriptive study using an online survey distributed to members of the Spanish Society of Clinical Pharmacology bet…