Short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval: a target trial emulation

Abstract Objective To estimate the short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval (QTc) by emulating a published randomized controlled trial (RCT) using electronic health record (EHR) data, and to assess whether target trial emulation (TTE) can replicate RCT findings for a pharmacological safety outcome at substantially greater scale. Design Retrospective cohort study emulating a target trial, reported according to the Transparent Reporting of Observational St