Analytica Chimica Acta

Background Reliable annotation remains a major challenge in untargeted LC–MS-based metabolomics, lipidomics, and exposomics. Liquid chromatography–hydrogen/deuterium exchange–mass spectrometry (LC–HDX-MS) provides orthogonal structural information by revealing the number of exchangeable hydrogens within a molecule, thereby supporting functional-group assignment, distinguishing isomeric structures…

The present manuscript describes the development of a low-pressure gas chromatography-triple quadrupole mass spectrometry method for the determination of multi-pesticide residues in white wine, with a specific focus on the enantiomeric separation of chiral pesticides. For such an objective, a wide-bore γ-cyclodextrin-based analytical column was evaluated under low-pressure conditions, with the ai…

Halogenated compounds are pollutants of international concern because of their persistence and resistance to degradation in the environment. However, their robust C–Cl and C–F bonds have made precision and accurate measurements of carbon stable isotope ratios (δ 13 C) using liquid chromatography–isotope ratio mass spectrometry (LC-IRMS) challenging. We developed a high-temperature combustion inte…