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Yan Zhou·...·Yuehan Wang

28d ago

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TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury

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29d ago

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Xing-xing Tu·+6 more

29d ago

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4/24/2026

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Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition

Candela Cives-Losada·+10 more

4/23/2026

Hepatoblastoma (HB) is the most common malignant liver tumor in children. One-fifth of patients exhibit a poor prognosis due to resistance to conventional chemotherapy, which typically includes doxorubicin. One of the underlying mechanisms is drug efflux through the MDR1 export pump. This study aims to explore pharmacological strategies for sensitizing HB by inhibiting MDR1. A panel of compounds,…

Drug Transport and Resistance MechanismsHealth SciencesMedicineOncology

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