Frontiers in Neurology

Background The optimal timing for surgical decompression in acute traumatic cervical spinal cord injury (SCI) remains a subject of intense clinical debate. Objective To evaluate the comparative efficacy and safety of ultra-early (<24 h), early (<72 h), and delayed surgery using a network meta-analysis (NMA) framework. Methods A systematic search of PubMed, Embase, and Web of Science…

Objective Structured tracheostomy decannulation pathways specifically tailored to patients with prolonged disorders of consciousness (pDoC) after brain injury remain limited. We aimed to describe a stepwise decannulation pathway and evaluate its feasibility and safety in this population. Methods We retrospectively reviewed consecutive tracheostomized patients with pDoC after brain injury admitted…

Human motor behaviour emerges from the dynamic interplay between the developing nervous system and the musculoskeletal apparatus, progressing from spontaneous fetal movements to postural control and early locomotion, including interpersonal coordination. Careful analyses of these behaviours may provide insight into the functional integrity of spinal and supraspinal networks, and early detection o…

Purpose To investigate the mechanism of electrothermal acupuncture in alleviating postherpetic neuralgia (PHN). Patients and methods A rat model of PHN was created with RTX injection, and electrothermal acupuncture (ETA) was applied at trigger points. Pain sensitivity was assessed using the von Frey test for PWT. ATP levels were measured colorimetrically, ROS via DCFH-DA fluorescence, and pro-inf…

Introduction Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. Ultrasonography (USG) enables measurement of the median nerve cross-sectional area (CSA) and quantitative assessment of hand muscles. This study aimed to evaluate the diagnostic accuracy of USG findings compared with electrophysiological studies in CTS. Methods In this prospective cross-sect…

Neuromuscular impairments are common in people with multiple sclerosis (pwMS), often beginning subclinically in early disease stages and contributing to long-term disability. Traditional clinical tools such as the Expanded Disability Status Scale (EDSS), however, lack sensitivity for detecting subtle neuromuscular dysfunction. In recent years, jump assessment has emerged as a digital, performance…

Minor Neurological Signs, also referred to as neurological soft signs, are subtle abnormalities detected during neurological examination that do not meet criteria for major focal deficits. They are increasingly considered indicators of variability in neurodevelopment, likely reflecting differences in sensorimotor integration and maturation of cortico–subcortical networks. This mini review summari…

Background Indications for patent foramen ovale (PFO) closure after ischemic stroke are primarily guided by the Risk of Paradoxical Embolism (RoPE) score and the PFO-associated Stroke Causal Likelihood Classification (PASCAL). Their application in routine care, however, is not well characterized. This study describes real-world management of patients with PFO presenting with ischemic stroke or tr…

Background Insomnia markedly impairs health and quality of life. This study used the 2022 National Health Interview Survey (NHIS) data to explore the relationships among dysphagia duration, dysphonia duration, and insomnia. Methods With the 2022 NHIS data, participants were stratified into insomnia and non-insomnia groups. Chi-square tests assessed group differences in dysphagia/dysphonia duratio…

Objective To evaluate the efficacy of postoperative screening for distress symptom cluster in patients undergoing surgery for pituitary adenoma (PA). Methods Prospectively collected data of 334 patients were reviewed. Patients undergoing screening were included in screening cohort. A 1:1 propensity-score matching was applied to select controls. Primary endpoint was Patient Reported Outcomes Measu…

Purpose To quantify optical coherence tomography (OCT)-derived retinal layer reflectivity and retinal thickness changes in acute central retinal artery occlusion (CRAO) for rapid diagnosis and stratification of ischemic tissue state, referenced to the clinically relevant 4.5-h window for reperfusion therapies. Methods This retrospective multicenter study included 39 patients with unilateral acute…

Background Post-traumatic hydrocephalus (PTH) and contralateral subdural effusion (cSDE) are common complications after decompressive craniectomy (DC) in severe traumatic brain injury. However, their concurrent occurrence poses diagnostic and therapeutic challenges. This study aims to analyze the clinical features, radiological progression, and treatment outcomes of this condition. Methods We ret…

Multimodal neuroimaging plays an indispensable role in the diagnosis, monitoring, and therapeutic evaluation of monoclonal antibody (mAb) therapies for Alzheimer's disease (AD). Structural MRI (sMRI) enables early detection of cerebral atrophy and amyloid-related imaging abnormalities (ARIA), a critical adverse effect associated with anti-Aβ immunotherapies. Positron emission tomography (PET) pro…

Introduction Carotid web (CaW) is an underrecognized variant of fibromuscular disease increasingly implicated in cryptogenic ischemic stroke. Several morphologic features, including lesion length, proximal angulation, and pocket size, have been associated with symptomatic presentation. However, no pragmatic prediction score has been validated to stratify asymptomatic patients. Methods We performe…

Objective To systematically evaluate the efficacy of blood flow restriction training (BFRT) for lower limb dysfunction in stroke patients. Methods Randomized controlled trials published up to October 2025 were retrieved from CNKI, Wanfang, VIP, SinoMed, PubMed, Embase, Web of Science, and Cochrane Library. The control group received conventional rehabilitation, while the intervention group receiv…

Objective This study conducted a network meta-analysis to systematically evaluate and compare the effectiveness of acupoint-based stimulation and manual therapies for cervicogenic vertigo. We examined needling-based stimulation, including manual acupuncture and electroacupuncture; thermal stimulation through moxibustion, including warm-needle techniques; acupotomy; manual therapy including tuina …

Background Despite the widespread establishment of stroke centers, delays in pre-hospital and in-hospital care persist. To date, no studies have investigated the role of accompanying authorized surrogates in early emergency care timelines and the outcomes of acute stroke. This study aimed to analyze the influence of types of surrogate decision-maker on critical time intervals and early clinical o…

Post-stroke cognitive impairment (PSCI) is a prevalent complication among stroke survivors. The core pathology of PSCI involves mitochondrial dysfunction. This review proposes that acupuncture may act as a multi-target regulator of mitochondrial homeostasis, potentially ameliorating PSCI through mechanisms such as improving core mitochondrial functions, including alleviating oxidative stress, cor…

Objective By developing and comparing various preoperative multimodal CT-based models to predict prognosis after successful recanalization in acute anterior circulation occlusive stroke, this study aimed to ascertain the prognostic assessment of patients following successful recanalization. Methods Patients with acute anterior circulation large vessel occlusion who underwent mechanical thrombecto…