Journal of the Neurological Sciences

Hypocapnia at <24 h post-stroke is associated with improved dCA (through higher phase). Beyond 24 h this association is lost and hypocapnia becomes predictive of poorer clinical outcome. Hypocapnia was prevalent in LSS but to a lesser extent than non-lacunar AIS. Future work should affirm the value of capnography in acute stroke care.

Impairments in the glymphatic system (GS) have been found in adults with acquired demyelinating syndromes (ADS), suggesting disruptions to the brain's waste clearance system may contribute to disease symptoms. However, this system has not been well characterized in pediatric ADS (PADS) populations. In the present study, we assessed the GS function in 15 children with PADS using the recently devel…

Multiple sclerosis (MS) arises from the convergence of polygenic immune susceptibility, environmental exposures, and infectious determinants, none of which alone is sufficient for disease expression. More than 200 genetic variants contribute to MS risk, with the HLA-DRB115:01 haplotype providing the strongest effect within a broader network of immune-regulatory loci. Functional genomic evidence s…

The factors interacting with MS fatigue need consideration when managing this prevalent symptom. In addition, their effect should be accounted for in any MS trial where fatigue is an outcome.

A longer duration of CLEE is associated with better outcomes in WwMS, while menopause appears to be linked to increased brain atrophy. Larger clinical studies are warranted to further explore these findings and clarify the relationships between CLEE, menopause and MS outcomes.

CRD420251182535.