Evidence for compromised function of the glymphatic system in pediatric acquired demyelinating disorders
Florencia Ontiveros·Eric E. Nelson·Adam Webb·Camille Wilson·Kristen R. Hoskinson·Whitney I. Mattson·Alexander Douma·Aaron S. McAllister·Kelsey E. Poisson
Impairments in the glymphatic system (GS) have been found in adults with acquired demyelinating syndromes (ADS), suggesting disruptions to the brain's waste clearance system may contribute to disease symptoms. However, this system has not been well characterized in pediatric ADS (PADS) populations. In the present study, we assessed the GS function in 15 children with PADS using the recently developed diffusion tensor along the perivascular space (DTI-ALPS) method. DTI-ALPS was also assessed in a