Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin

Abstract ACTH-producing pancreatic neuroendocrine neoplasms (PanNENs) are a rare aggressive subset of panNETs associated with clinical symptoms of ectopic Cushing syndrome. Until recently, their molecular pathogenesis remained poorly understood. Following our prior study highlighting high frequency of gene fusions (mostly EWSR1::BEND2 ) in them, we herein document our experience with 5 new tumors…

Abstract Context: In situ hybridization (ISH) for kappa and lambda immunoglobulin light chains is an important ancillary tool for identifying monoclonal plasma cell or B-cell infiltrates in kidney biopsies. We observed that kidney biopsy cores transported in Michel transport medium (MTM) showed markedly diminished or absent kappa and lambda ISH signals compared with their formalin-fixed counterpa…

Abstract Ovotesticular disorders of sex development (DSD) are variations in sex development characterized by the presence of both ovarian and testicular parenchyma in the same individual, with histopathologic confirmation being mandatory for accurate diagnosis. FOXL2, a transcription factor involved in ovarian differentiation and maintenance, has emerged as a potential immunohistochemical marker …