Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin

Abstract Surgical pathology represents a resource-intensive component of healthcare systems due to continuous operation, energy-demanding infrastructure, extensive use of hazardous chemicals, and high volumes of single-use consumables. Despite this, surgical pathology has historically received limited attention within sustainability research and policy frameworks. This narrative review examines t…

Abstract Parallel to and after publication of the WHO 2024 classification of head and neck tumors, several developments concerning known existing salivary gland tumor entities, but also proposing new evolving tumor entities have been published. This review article describes the most important new developments in salivary gland pathology published through 2022–2025, that were not included in the 5…

The evaluation of HER2 gene amplification is a time-consuming process that requires quantifying a large number of signals in cancer cells to ensure reproducible results, a task that can be assisted by image analysis (IA) tools. This study aimed to develop and validate an artificial intelligence-based cancer cell detection model for detecting breast carcinoma in bright-field in situ hybridization …

Xanthogranulomatous ureteritis (XGU) has been described as a rare, mass-forming, locally destructive ureteral inflammatory lesion, most often associated with enteric Gram-negative bacilli. The current case report documents that XGU may be associated with the urinary tract congenital anomalies including a complete duplex kidney, ureter duplex, and ureterocele. An overlap with the definition of mal…

Accurate assessment of Ki67, a marker of cellular proliferation, is critical for breast cancer diagnostics and treatment decision-making. This study evaluates an automated Ki67-area identification approach, combined with digital image analysis (DIA) for exact Ki67 quantification. A total of 61 tissue samples from breast cancer patients from two clinical trials (GeparSixto and GeparSepto) were ana…

In recent years, peripheral type SCC with alveolar filling growth pattern was described with an increasing prevalence in up to 55% of patients. We describe a series of rare growth pattern of SCC with subtotal or partial growth of tumor cells under reactive type II pneumocytes, termed subepithelial growth. Retrospective case series of 19 resections specimens and 3 biopsies with subepithelial growt…

Abstract Gastric carcinomas occasionally harbor genetic alterations of JAK2 and NOTCH2 . In this study we investigated the tumor biological significance of JAK2 and NOTCH2 in gastric carcinoma. The expression of JAK2 and NOTCH2 was studied by immunohistochemistry using whole mount tissue sections obtained from 447 resection specimens of gastric adenocarcinomas. A Histoscore was generated and expr…