Caltech Library

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The appearance of nuclear magnetic resonance spectra of systems of nuclei in which exchange of magnetic environment occurs, both for intra- and inter-molecular cases, has been related to the exchange rate, yielding methods whereby parameters of kinetic nnd thermodynamic interest may be easily obtained. Computer programs have been written for the IBM 7094 which compute the spectra for certain simp…

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The physical binding of benzpyrene-H3 with coil form of thymus DNA has been studied. Covalent linkage between the benzpyrene-H3 or the degradation products of benzpyrenc-H3 and DNA was generated by photoradiation at the absorption band of benzpyrene with the "yield" of photoproduct around 50%. This finding has been conclusively supported by experiments with precipitation and extraction, sedimenta…

Procedures were developed to synthesize as easily and cheaply as possible various optically active tartaric acid methyl esters for use in studies of enzymatic hydrolysis. The compounds prepared were d and l dimethyl tartrate and l monomethyl tartrate free from diester. Purity was checked by chromatographic and melting point tests.

The chlorination of trans-△2-octalin has been shown to produce diaxial-dichlorides and diequatorial-dichlorides in the ratio of two to one. The results are explained in terms of a mechanism involving a cyclic chloronium ion.

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The synthesis of 2-[p-(2'-hydroxyethoxy)phenyl]ethylamine (I) and the subsequent aqueous acid deamination has been carried out and the major products identified. The deuterium- labeled amine (Ia) has been similarly deaminated and the extent of rearrangement of the methylene groups has been determined to be 40% by means of nuclear magnetic resonance spectroscopy. See PDF abstract for figures.

Nuclear shielding theory is reviewed. General expressions are developed for the shielding using an extension of the Chan- Das formalism, including vibration and rotation. The James Coolidge wave functions by Kolos and Roothaan for H2 are employed. The electronic integrals for the diamagnetic part of the shielding are reduced to well-known functions. Flowcharts are presented to outline machine com…

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Preliminary steps in the synthesis of "congressane 63" (pentacyclotetradecane) have been studied. Methods have been investigated to prepare the starting material, 1,4-cyclohexadione, its ethylene glycol-monoketal, and the initial products of the synthesis. The latter include the eneamine, bicyclo acrolein adduct, and the pyrolysis elimination of the amine group. The acrolein addition and the pyro…

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The purpose of this investigation was to show interaction between iodoform and other small inert molecules as evidence supporting Dr. Linus Pauling's General Theory of Anesthesia. Such interaction was taken to be indicated by the increased solubilization of iodoform in the presence of other small inert molecules in aqueous solution. Such increased solubilization was not observed with nitrogen, ca…

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The measured heats of solution of methyl alkyl ketones do not correlate with their relative dissociation constants. The heats of solution are explicable if hydrogen bonding is considered.

Heat denaturation studies of desoxyribonucleic acid in sodium chloride and tetramethylammonium chloride solutions of low ionic strength have shown that DNA melts at a lower temperature in the TMACl solutions. Electrophoresis experiments with DNA in a low ionic strength TMACl medium have disclosed that DNA has only a slightly higher mobility in 0.01 F TMACl than in 0.01 F NaCl.

The affinity constants (nk) where n is the number of the binding sites and k is the average association constant of each site, between certain compounds and nucleic acids, have been measured by equilibrium dialysis at 5°C in buffered solutions containing 0.5 M salt. The order of the increasing affinity constants of these compounds to the nucleic acids was found to be: thymine ≪ adenine, caffeine …

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No abstract.