PubMed

Tau aggregation is a key pathological feature of neurodegenerative diseases termed tauopathies. Identifying the various cellular factors that function to prevent tau aggregation in cells can generate key insights into how to mitigate diseases associated with protein misfolding. During an investigation into developing purification methods for the protein tau, we observed that isolates of Escherich…

= .05). Time to first rescue analgesia increased by 1.54 hours, and ambulation outcomes consistently showed improvement in the dexmedetomidine group. This analysis supports the use of dexmedetomidine as an adjunct for ACB in TKA. However, significant heterogeneity among studies limits applicability of this analysis's findings. Clinicians are advised to consider this when making practice decisions.

This study explored job satisfaction and turnover intentions among certified registered nurse anesthetists (CRNAs) in a prominent Southern California health system. Job satisfaction and turnover intentions were measured using the Misener Nurse Practitioner Job Satisfaction Scale and Turnover Intention scales, respectively. Of the 60 CRNAs who completed the survey, 30% expressed turnover intention…

Background: Combining power training (PT) with endurance training (ET) offers health benefits for older adults. However, little is known about the effects of PT plus ET on arterial stiffness and hemodynamic parameters in previously trained hypertensive older adults. Additionally, the effects of exercise order-PT followed by ET versus ET followed by PT-on arterial stiffness and hemodynamic paramet…

= .020). In the full logistic regression model, ADHD (aOR, 1.17; 95% CI, 1.10-1.24) was associated with increased odds of CE use. The Backward stepwise selection model retained ADHD and anxiety as significant predictors.

Background: The motivations and attitudes of caregivers strongly influence the care they provide. Motivation is also a central component in staff retention and care consistency, whereas attitude shapes delivery and degree of person-centeredness in care. Although caregiver attitudes and motivations have been examined separately in dementia care research, these constructs have not been comprehensiv…

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed to treat type 2 diabetes mellitus and later became widely used for the management of obesity. Recent evidence includes off-label uses for substance use disorders; nicotine and alcohol dependence; neurodegenerative diseases; and cardiovascular, kidney, and liver diseases. Certified registered nurse anesthetists (CRNAs) are likely …

General anesthesia increases the morbid risk for both mother and infant during a cesarean delivery. Failed or asymmetric blocks can force providers to turn to a general anesthetic precipitously. A true one-sided spinal block, with complete absence of anesthesia on one side despite correct subarachnoid technique, is rare and not well characterized in the literature. In this case, a 32-year-old mul…

< 0.001). Predictive factors for substance use include enrollment period greater than 24 months, male gender, and elevated PSS-10 and DAST-10 scores.

Background: Behavioural and psychological symptoms of dementia (BPSD) are complex to assess and manage, and a lack of updated clinical practice guidelines (CPGs) leads to variation in clinical practice. When generating CPGs, involvement of end-users in developing and prioritizing topics is key to creating effective recommendations. Methods: To inform the creation of a CPG for the management of BP…

Background: Falls are a leading cause of injury and loss of independence in older adults. Impaired balance is a modifiable risk factor yet traditional rehabilitation approaches may not fully address balance control. Augmented reality (AR) provides an interactive method to support balance training and fall prevention. This scoping review summarizes key characteristics of AR interventions for balan…

Gabapentin is widely used in perioperative analgesic protocols. Many clinical studies supporting the safety and analgesic efficacy of gabapentin for postoperative pain have been published over the last two decades. Several studies, many recently, have questioned its effectiveness and safety for perioperative pain management in early recovery after surgery (ERAS) and non-ERAS protocols leading to …

Background: Comprehensive geriatric assessment (CGA) is the reference standard for diagnosing and managing frailty. By evaluating a broad range of health, functional, cognitive, and social problems, the CGA enables the construction of a deficit accumulation Frailty Index (FI-CGA). Recent advances have integrated the electronic CGA (eCGA) into electronic health/medical records and other digital pl…

Background/Objectives: Specialized training is necessary for health-care providers such as physicians, nurses, and social workers, to be able to accurately perform decision-making capacity assessments (DMCAs). With an increasing demand for flexible, accessible education, there is growing interest in utilizing online training modules to keep health-care providers up to date on current best practic…

BACKGROUND: Current neonatal resuscitation program standards recommend the use of real-time documentation completed by a designated scribe. Accurate documentation of resuscitation interventions after delivery is an important component of future care for the newborn. PURPOSE: The purpose of this article was to review current practices in the documentation of neonatal resuscitation practices, how t…

A Comprehensive Geriatric Assessment (CGA) completed by a geriatrician assessing an older person living with frailty and multiple comorbidities involves longer visit durations than standard General Internal Medicine (GIM) consultations, reflecting the need for detailed evaluation. Medical trainees have little formal education about how they will be remunerated as specialists or that there are dif…

Background: Deciding whether to continue driving or transition to alternative means of transportation is a challenging issue for older adults in preventive care settings. This study aimed to identify potential associations between the Japanese version of the Montreal Cognitive Assessment (MoCA-J) and driving as the primary mode of transport among older adults. Methods: The participants of this cr…

= .001). Overall, we found that deep sedation is feasible for TPVI and in this retrospective study was associated with decreased periprocedural complications.